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Adam was also surprised, and offered two explanations: either the particular GIPR variant genuinely does not affect weight loss, or the study did not include enough tirzepatide users to detect the effect

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The body weight-lowering effects of multi-agonists are primarily due to their anorectic actions As multi-agonist therapies elicited a marked reduction in body weight during the first week of treatment, we assessed the putative mechanisms associated with such weight loss

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